It should not be a problem. It can also be due to values changing because of formulae. I think it's normal as I experience it almost everytime when opening my workbooks.

On 20 January 2012 14:42, Rad! <conradakunga@gmail.com> wrote:
Probably you have a macro running in that workbook


On Friday, January 20, 2012, Chege <compulinekenya@gmail.com> wrote:
> Dear Skunks,
> Am  receiving  this msg  from  some pcs when i open an excel document
> even without making any  changes ..anyone  has a solution to this ..
> EXcel error  msg  "Do you want to save  changes  you made......"
>
>
> rgds
>
> Chege
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